Organization of growth plates of bones and of articular cartilage

Organization of biological tissue often reflects normal biological function, while disorganization corresponds to abnormality. The growth plates of bones and articular cartilage in joints are each highly organized tissue, the first responsible for bone growth and the second responsible for adequate cushioning between bones. Cells known as chondrocytes generate both growth plate and cartilage. We will investigate the organization and disorganization of the two tissues revealed on imaging of normal and genetically mutated mice. We will develop algorithms to read salient information from the images, and criteria to assess and test patterns. The outcome will assist molecular biologists to identify the phenotypes specific to the mutated genes.